WRAIR was a pioneer in early testing of Ebola vaccine candidates, utilizing its established network of HIV study clinical study sites in Africa to pivot towards Ebola countermeasures.
In 2014, WRAIR accelerated the advancement of the rVSV-ZEBOV Ebola vaccine candidate in a first-in-human Phase I clinical trial within just 11 weeks in the midst of the West Africa outbreak. The findings from this trial executed at the WRAIR in Silver Spring, Maryland selected the vaccine dose that was used for the field efficacy study in Guinea. The vaccine, Ervebo, became the first FDA-approved vaccine for the prevention of Ebola virus disease (EVD), caused by Zaire ebolavirus.
In 2019, WRAIR's partner site in Uganda, MUWRP, began clinical studies using an Ebola Sudan vaccine developed by the NIH Vaccine Research Center.
To date, the WRAIR clinical trials network has completed eight clinical trials of five different investigative Ebola virus vaccine candidates, more than any single institution in the world.
Ebola Vaccine Legacy
2019
Phase 1 study using cAd3-EBO S (Sudan) vaccine (Uganda)
Tested an Ebola Sudan vaccine developed by the NIH Vaccine Research Center
2016
Initiated Multi-site Phase 1/2a Ebola vaccine trial (USA and Africa)
Tested Ad26.ZEBOV and MVA-BN-Filo to expand on safety and immunogenicity data and test other regimens. This study was supported by MHRP and Crucell Holland
2015
Began Phase 2 vaccine study in Nigeria using ChAd3 vaccine (Nigeria)
First Ebola vaccine study in Nigeria testing ChAd3-EBO-Z vaccine candidate supported by GSK
2015
Tested ChAd3 vaccine in phase I study (Uganda)
Collaboration to explore long-term antibody responses.
2014
Conducted Phase I Clinical Testing VSV Vaccine Candidate at WRAIR (USA)
NEJM article shows vaccine safe and produced robust immune response. Informed dosing for larger clinical studies.
2009
Conducted First Ebola Vaccine Clinical Trial in Africa (Uganda)
Phase 1 clinical trial of NIH’s early DNA vaccine candidate that informed development of next generation (ChAd3) vaccine.